I...have been bawling my eyes out read this manga. So amazingly well written. Translation is kind of shaky so far, but the power of the story comes through anyway. I.S. - Otoko demo onna demo nai sei
(Neither Male Nor Female)
I just finished Vol. 6. DON'T SPOIL ME FOR ANYTHING. Will type up thoughts once I'm done reading all 17 volumes.
Description from mangafox:
IS (Pronounced Aiesu in Japanese) is not your everyday manga. This manga strictly deals with cases of intersexuality. IS stands for Inter Sexuality.
This manga deals with very serious issues concerning intersexual people. The pain they go through, the troubles they confront, and ultimately their inability to reproduce and even find a partner who will accept them as they are - It's all there in a form of manga.
The series is consisted of cases, each dealing with different people - although some cases are much longer and more dramatic than others.
The first volume is about the case of Hiromi and the case of Ryoma. The third case is of Haru and characters related to him.
If you don’t know what intersexuality is, refer to the Wikipedia on Intersex.[Edit]
Volume 1 contains two short stories that are both quite good, but it's in Volume 2 that the main story starts and I start bawling my eyes out.